Rebecca Pearson's Death 

Ginny Weasley, who appears far less feisty in the movies than she does in the books. It's unfortunate since along the course of the books, Ginny develops into a strong, self-reliant member of Harry's friend group.

Rebecca Learns of Jack's Demise

One of the saddest scenes from all 106 episodes of This Is Us will always be Jack's death, and Rebecca's response, which Mandy Moore masterfully captures, further heightens the tragedy.

Toby Informs Kate He Notices It

It's comforting to witness Kate's final move on in This Is Us season 6 after suffering through Kate and Toby's marital problems and divorce together.

Rebecca's Family Meeting 

In "Taboo," the seventh episode of season six of This Is Us, Rebecca utilizes a family vacation to explain to the kids how she wants her final days to be spent.

Deja's Departure

Randall is the one who feels the brunt of Deja's difficult decision to move back in with her birth mother and leave the Pearsons.

The Group Therapy Session 

While there are numerous scenes in Kevin's addiction narrative that will make viewers cry, one of the most powerful ones is the group therapy session the Pearsons attend while he is in treatment.

Kate Introducing Toby To Jack 

"The Game Plan" is centered around the football passion of the Pearson family. In the future timeline of This Is Us, Kate discloses that Jack has passed away following a whole plot point in which she acts strangely in response to Toby's offer to attend the game.

Kevin Comforting Randall During His Breakdown 

The loss of a character is the subject of many of This Is Us' most tragic scenes, but the sequence from season one where Randall feels the full weight of his issues fall on him at once is particularly moving for other reasons.

William Dying Of Cancer 

In the first season of This Is Us, Randall locates and gets to know his biological father. Sadly, their romance is short-lived because William passes away from cancer shortly afterward.

Rebecca & Jack Lose The Baby 

The sadness of losing someone is explored in This Is Us much before Jack or Rebecca pass away. In fact, the couple's loss of one of their triplets during childbirth—the very catastrophe that leads them to adopt Randall—occurs in the pilot episode of This Is Us.